The Most Prescribed Self-Injectable Epinephrine

EpiPen® (epinephrine) 0.3 mg and EpiPen Jr (epinephrine) 0.15 mg Auto-Injectors contain epinephrine. According to the NIH-NIAID food allergy guidelines, epinephrine is the first-line treatment for life-threatening allergic reactions (anaphylaxis). EpiPen Auto-Injector is used to treat signs and symptoms of anaphylaxis, some of which include hives, redness of the skin, tightness in the throat, breathing problems and/or a decrease in blood pressure. Anaphylaxis can be caused by triggers such as food, stinging and biting insects, medicines, latex, or even exercise.

You never know when anaphylaxis will occur, so it’s important that you and your loved ones be careful to avoid allergens. Make sure you speak with your health care professional about how to identify the signs and symptoms of anaphylaxis. If you, your child or someone you're caring for shows signs or symptoms of anaphylaxis, inject the health care professional-prescribed EpiPen or EpiPen Jr immediately and seek emergency medical attention.

EpiPen and EpiPen Jr Auto-Injectors are available in 2-Pak cartons. This follows NIH-NIAID food allergy guidelines that recommend people at risk for anaphylaxis have two doses of epinephrine available. The EpiPen 2-Pak provides an additional dose if needed during a life-threatening allergic reaction. More than two doses of EpiPen Auto-Injector should be administered only under direct medical supervision. Talk to your health care professional if you need additional EpiPen 2-Pak Auto-Injectors to keep at work, school or other locations. Each EpiPen 2-Pak also includes a training device.

Important Safety Information

EpiPen® (epinephrine) Auto-Injectors contain a single dose of epinephrine, which you inject into your outer thigh. DO NOT INJECT INTO YOUR VEIN, BUTTOCK, FINGERS, TOES, HANDS OR FEET. In case of accidental injection, please seek immediate medical treatment. Epinephrine should be used with caution if you have heart disease or are taking certain medicines that can cause heart-related (cardiac) symptoms.

Tell your doctor if you have certain medical conditions such as asthma, depression, thyroid disease, Parkinson’s disease, diabetes, high blood pressure and heart disease, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Be sure to also tell your doctor all the medicines you take, especially medicines for asthma. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you take the EpiPen or EpiPen Jr Auto Injector.

The most common side effects may include increase in heart rate, stronger or irregular heartbeat, sweating, nausea and vomiting, difficulty breathing, paleness, dizziness, weakness or shakiness, headache, apprehension, nervousness or anxiety. These side effects usually go away quickly, especially if you rest.

Talk to your health care professional to see if EpiPen or EpiPen Jr Auto-Injector is right for you.


EpiPen® (epinephrine) 0.3 mg and EpiPen Jr® (epinephrine) 0.15 mg Auto-Injectors are for the emergency treatment of life-threatening allergic reactions (anaphylaxis) caused by allergens, exercise, or unknown triggers; and for people who are at increased risk for these reactions. EpiPen and EpiPen Jr are intended for immediate self administration as emergency supportive therapy only. Seek immediate emergency medical treatment after use.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

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