What Is Anaphylaxis?

What Is Anaphylaxis?

Anaphylaxis is a severe systemic allergic reaction resulting from exposure to allergens, which is rapid in onset and can cause death.1,2 Anaphylaxis is triggered by a wide range of allergens, including but not limited to foods, insect stings and bites, medications and latex.1-3 While less common, anaphylactic reactions can also be triggered by exercise.1,3 When no triggers for an anaphylactic reaction can be identified, a diagnosis of idiopathic anaphylaxis is made.1,3 Anaphylaxis usually occurs outside the presence of health care professionals and thus poses a serious health consequence if at-risk patients are not identified and prepared.1,2,4,5 If patients are appropriately prepared, however, anaphylaxis is a largely preventable, albeit
long-term, disease.5

Indications

EpiPen® (epinephrine) 0.3 mg and EpiPen Jr® (epinephrine) 0.15 mg Auto-Injectors are indicated in the emergency treatment of type 1 allergic reactions, including anaphylaxis, to allergens, idiopathic and exercise-induced anaphylaxis, and in patients with a history or increased risk of anaphylactic reactions. Selection of the appropriate dosage strength is determined according to body weight.

Important Safety Information

EpiPen Auto-Injectors should only be injected into the anterolateral aspect of the thigh. DO NOT INJECT INTO BUTTOCK, OR INTRAVENOUSLY.

Epinephrine should be used with caution in patients with certain heart diseases, and in patients who are on drugs that may sensitize the heart to arrhythmias, because it may precipitate or aggravate angina pectoris and produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported in patients with underlying cardiac disease or taking cardiac glycosides or diuretics. Patients with certain medical conditions or who take certain medications for allergies, depression, thyroid disorders, diabetes, and hypertension, may be at greater risk for adverse reactions. Other adverse reactions include transient moderate anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.

EpiPen and EpiPen Jr Auto-Injectors are intended for immediate self-administration as emergency supportive therapy only and are not intended as a substitute for immediate medical or hospital care.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For additional information please contact us at 800-395-3376.