Frequently Asked Questions

Frequently Asked Questions

Who is EpiPen® (epinephrine) Auto-Injector indicated for?

EpiPen Auto-Injector is indicated for patients with a history of anaphylaxis as well as for patients at risk for anaphylaxis (see “Identifying At-Risk Patients” section).1

What are the directions for use?

To download the Patient Information, including complete directions for use, please click here.

How should my patients dispose of a used EpiPen Auto-Injector?

It is important to communicate to your patients that expired and used auto-injectors must be disposed of properly.2 They should be taken to a doctor’s office or to a hospital for proper disposal.3 Also, remind your patients to obtain a replacement for any EpiPen Auto-Injector used or disposed of.3

When should a second dose of epinephrine be given?

With severe persistent anaphylaxis, repeated injections with additional EpiPen Auto-Injectors may be necessary.1,4-6 Up to 20% of patients who receive an initial first dose of epinephrine require a second dose, because of either a biphasic reaction or ongoing symptoms.5 In such cases, the epinephrine dose can be repeated every 5-15 minutes, as needed.5 Remind your patients that more than 2 doses of the EpiPen Auto-Injector should be administered only under direct medical supervision.1

How chemically stable is epinephrine?

Epinephrine solution deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin. Patients should be instructed to visually inspect the epinephrine solution periodically for particulate matter and discoloration. Patients should also be advised to replace their EpiPen or EpiPen Jr Auto-Injectors if the epinephrine solution contains particulate matter or develops a pinkish or brown color, because these changes indicate that the effectiveness of the drug product may have decreased or been affected. It is important to follow recommended storage conditions.1

How should the EpiPen Auto-Injector be carried?

Until the EpiPen Auto-Injector needs to be used, it should be carried in the carrier tube with the blue safety release cap on.3

How should the EpiPen Auto-Injector be stored?

EpiPen and EpiPen Jr Auto-Injectors should be stored in the carrier tube provided at a temperature of 25ºC (77ºF); however, temperature excursions between 15ºC and 30ºC (59ºF to 86ºF) are permitted.1 EpiPen and EpiPen Jr Auto-Injectors should not be stored in refrigerators or in a vehicle’s glove box.1,3 The auto-injectors should not be exposed to extreme heat or cold.3

My patient accidentally injected himself/herself with an EpiPen Auto-Injector. What should I do?

Because epinephrine is a strong vasoconstrictor, accidental injection into fingers, hands or feet may result in decrease or loss of blood flow to these areas. The patient should be advised to go immediately to the nearest emergency room and to inform the health care professional in the emergency room of the location of the accidental injection.1

Indications

EpiPen® (epinephrine) 0.3 mg and EpiPen Jr® (epinephrine) 0.15 mg Auto-Injectors are indicated in the emergency treatment of type 1 allergic reactions, including anaphylaxis, to allergens, idiopathic and exercise-induced anaphylaxis, and in patients with a history or increased risk of anaphylactic reactions. Selection of the appropriate dosage strength is determined according to body weight.

Important Safety Information

EpiPen Auto-Injectors should only be injected into the anterolateral aspect of the thigh. DO NOT INJECT INTO BUTTOCK, OR INTRAVENOUSLY.

Epinephrine should be used with caution in patients with certain heart diseases, and in patients who are on drugs that may sensitize the heart to arrhythmias, because it may precipitate or aggravate angina pectoris and produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported in patients with underlying cardiac disease or taking cardiac glycosides or diuretics. Patients with certain medical conditions or who take certain medications for allergies, depression, thyroid disorders, diabetes, and hypertension, may be at greater risk for adverse reactions. Other adverse reactions include transient moderate anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.

EpiPen and EpiPen Jr Auto-Injectors are intended for immediate self-administration as emergency supportive therapy only and are not intended as a substitute for immediate medical or hospital care.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For additional information please contact us at 800-395-3376.